2015 Fiscal Year Final Research Report
Effect of antipsychotics on efficacy of D-serine
| Project/Area Number |
25460224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIGUCHI Yoshikazu 東邦大学, 薬学部, 助教 (60459823)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 統合失調症 / D-セリン / リスペリドン / マイクロダイアリシス / LC-MS/MS |
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| Outline of Final Research Achievements |
It has been reported that D-serine administration with antipsychotics was effective for the treatment of schizophrenia. An inhibitory effect of D-amino acid oxidase (DAO) activity by several antipsychotics or mood stabilizer etc. was firstly investigated by in vitro experiment, and we found that second-generation antipsychotics, risperidone (Ris) and blonanserin revealed relatively intense inhibitory actions of in vitro DAO activity. Next, Ris followed by D-serine was administered intraperitoneally to rats, and the D-serine levels in rat plasma or brain (striatum) with or without Ris pretreatment were examined by HPLC with fluorescence detection. Consequently, D-serine levels in rat plasma and microdialysis sample from striatum in rat brain were significantly increased in rats pretreated with Ris.
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| Free Research Field |
分析化学
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