2015 Fiscal Year Final Research Report
Delivery to the skin of a substance having an antioxidant action to control the process of skin aging
| Project/Area Number |
25460225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | レスベラトロール / プテロスチルベン / メラニン細胞 / 経皮吸収 / アマンタジン |
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| Outline of Final Research Achievements |
This study investigated transdermal delivery and permeability to the brain of resveratrol (RES), which is functional polyphenol contained in red wine. Pterostilbene and acetylpterostilbene were synthesized as a RES derivative, and they were evaluated for their inhibitory activities of melanogenesis in B16 mouse melanoma cells.The amount of accumulated penetrations of RES with the fatty ester C8 in 8 hours increased to the skin by about 12 times as compared with the case where there is no absorption enhancer. We demonstrated that C8 is not only to promote the skin permeability of RES as absorption enhancers, but to have the action which also raises the transportability in the skin simultaneously.Like RES, PTE and the acetyl PTE have melanogenesis inhibition and showed clearly that one of mechanism has tyrosinase activity inhibition.
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| Free Research Field |
医療薬学
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