2015 Fiscal Year Final Research Report
Investigation for the mechanism to induce adverse drug reaction from database: Drug transporters involved in the induction.
| Project/Area Number |
25460231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YANO Yoshitaka 京都薬科大学, 薬学部, 教授 (60437241)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 副作用 / データベース / 腎障害 |
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| Outline of Final Research Achievements |
In this investigation, we screened Japanese Adverse Event Report (JADER) database. In addition, mechanism to induce adverse events was examined using in vitro experimental methods. At first, data files disclosed from PMDA was reconstructed to the relational database with File Maker or Microsoft Access. Based on these reconstructed databases, respective adverse events were extracted. It was found that some characteristics of patients were correlated with prognoses of adverse events. In addition, toxicities of the drugs were examined with cultured cells.
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| Free Research Field |
医療薬学
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