Functional analysis of cardiac precursor cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460244
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Hiroshima University
• Principal Investigator: Kokubo Hiroki 広島大学, 医歯薬保健学研究院(医), 講師 (10270480)
• Co-Investigator(Kenkyū-buntansha): 吉栖 正生 広島大学, 医歯薬保健学研究院, 教授 (20282626)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 心筋

Outline of Final Research Achievements

In this study, we found the new cardiac precursor population, which contributes to all heart components except for the right ventricle, by expression and lineage analysis of the gene related to the Wnt signaling. Studies with the knockout mice and cell culture system showed that Wnt signaling could regulate proliferation of the precursor cells rather than differentiation to the myocardium. Since Wnt signaling could not affect differentiation, the establishment of a culture system that maintained the undifferentiated state of cardiac precursor cells remained as a future assignment.

Free Research Field

発生遺伝学