2015 Fiscal Year Final Research Report
Role of the relation between morphology and function of sensory neuron in the development and evolution of sensory architecture
| Project/Area Number |
25460251
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including histology/embryology)
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Koji 東北大学, 生命科学研究科, 教授 (70261550)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 発生 / 進化 / 分化 / 一次感覚神経 / 脊髄神経節 / 神経堤細胞 / エンハンサー / Six遺伝子 |
|---|
| Outline of Final Research Achievements |
We found 1) the developmental mechanism assigning the location of sensory neuron inside or outside spinal cord is cell-autonomous manner and acts independently of the mechanism which defines or maintains the integrity of the boundary structure between the CNS and PNS, 2) Six1 controls the mechanism and relates it to gangliogenesis of sensory neuron via Neuropilin-Semaphorin pathway and 3) urodele amphibians might have a transitional sensory architecture followed by the exclusive DRG system acquired in amniote.
|
| Free Research Field |
発生生物、進化発生
|
