Tumor cell dynamism and molecular mechanism invloved in tumor vascular metastasis in novel cancer research model of zebrafish

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460262
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Hirosaki University
• Principal Investigator: Shimoda Hiroshi 弘前大学, 医学(系)研究科(研究院), 教授 (20274748)
• Co-Investigator(Kenkyū-buntansha): ISOGAI SUMIO 岩手医科大学, 医学部, 准教授 (60212966)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ゼブラフィッシュがんモデル / 腫瘍脈管新生 / 生体イメージング

Outline of Final Research Achievements

A novel cancer research model of transgenic zebrafishes, which allowed a precise analysis of cancer cell dynamism for metastasis through blood and lymphatic vasculature, was developed. Live imaging of human tumor cells in the metastasis model unveiled some unique patterns of tumor vascular invasion and of motion of tumor cells through vasculature. The zebrafish implanted with human pancreatic cancer cells producing VEGF-A often demonstrated focal growth of vascular endothelial cells at tumor invasion sites. The molecular mechanisms involved in tumor vascular invasion including microangiogenesis and/or lymphangiogenesis is under investigation.
達成度

Free Research Field

医歯薬学