Analysis of the distribution and differentiation potency of adipocyte precursor cells in mesentery of Suncus murinus

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460265
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: Yi Shuang-Qin 首都大学東京, 人間健康科学研究科, 教授 (70334753)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Yasuhiko 金沢大学, 医学系, 教授 (20313637)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腸間膜脂肪蓄積 / 脂肪幹細胞 / 脂肪移植 / Gold Thiglucose / Pioglitazone

Outline of Final Research Achievements

The adipocyte precursor cells existed with the epididymal, retroperitoneal, and subcutaneous white adipose tissue, but not in the mesentery in Suncus murinus. As a result of isolating a cell from a mesentery of the Suncus, and having cultured it, it did not differentiate to a maturity adipose cell at all.
In a fat transplant experiment of the Suncus, it did not lead to differentiation of the mesenteric tissues by transplanting a mesentery tissue under subcutaneous environment. There was little reduction of food consumption of the Suncus in a high-fat meal, however, as the caloric intake did not change to general meal every day, there was not the change of the weight, and there was not the formation of the mesenteric adipose. It was suggested that the Suncus had resistance for caloric load.

Free Research Field

消化器系自律神経と癌の転移