Role of the neuronal and non-neuronal regulatory mechanisms of the renal blood pressure

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460278
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Hyogo Medical University
• Principal Investigator: Maeda Seishi 兵庫医科大学, 医学部, 准教授 (10309445)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腎神経 / 自律神経 / 交感神経幹

Outline of Final Research Achievements

Topological analysis of the rat renal efferent nerve ganglia were observed by a specific neuronal tracing method with micro-capsule which introduce the fluoro-gold (FG) retrogradely into the renal nerve plexus. As the results, FG-labeled cells were observed to the sympathetic chain ganglia T10 to L1 and prevertebral suprarenal ganglia (SrG) while no labeled cells were observed to the parasympathetic motor nuclei. Tracer injection of FG into the cranial- or caudal-segment of the kidney was shown that the SrG neurons and T13 chain neurons may particularly innervate into the cranial- and caudal-segment, respectively. Novel renal ischemia/reperfusion model of rats which is preserved the renal nerves represented increasing in renal tyrosine hydroxylase immuno-reactivity but no apparent changes in the receptor expression. These indicate the hyper-activation of renal sympathetic nerves in this model and useful to investigate the effects of sympathetic activity in the renal I/R injury.

Free Research Field

神経解剖学、細胞生物学