2015 Fiscal Year Final Research Report
The role of EPAC in development of hypertension
| Project/Area Number |
25460296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 高血圧 / EPAC / ｃAMP |
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| Outline of Final Research Achievements |
We found that the salt-sensitivity of blood pressure was attenuated in Epac1 deficient mice. In addition, the aquaporin 2 (AQP2) and renin mRNA levels in the kidney of EPAC1KO mice were significantly lower than that in wild type (WT) mice. Consistently, water consumption was increased in the mice compare to WT mice, indicating that water reabsorption through AQP2 may be inhibited by EPAC1 deficiency.
These findings suggest that EPAC1 plays important role in maintaining the expression of renin and AQP2 in the kidney of mice. Through these mechanisms, Epac1 may be involved in the development of hypertension.
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| Free Research Field |
循環器病学
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