2016 Fiscal Year Final Research Report
Sexual differentiation of the sexually dimorphic nucleus of the preoptic area and the bed nucleus of the stria terminalis responsible for the gender identity.
| Project/Area Number |
25460320
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 脳の性差 / 性差形成機構 / エストロゲン / 性別違和 |
|---|
| Outline of Final Research Achievements |
Sex differences of the brain would be important for the gender identity, however, the mechanism of the sexual differentiation of the brain remains largely unknown. The sexually dimorphic nucleus of the preoptic area (SDN-POA) is thought to contribute to the gender identity. In this study, we examined the sexual differentiation of the SDN-POA using the organotypic brain slice cultures and time-lapse imaging in vitro to test the hypothesis that neural migration regulated by estrogen is critical for the sexual differentiation of the SDN-POA. The scattering neural migration by estrogen was observed in the masculinization of the SDN-POA. This estrogen induced scattering migration was mediated through the estrogen receptor alpha/Rac1/cofilin/actin pathway. These results suggest that scattering neural migration by estrogen is critical role for the masculinization of the SDN-POA.
|
| Free Research Field |
神経内分泌学
|
