Neural mechanisms of anapyrexia

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460325
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: National Institutes of Biomedical Innovation, Health and Nutrition (2015-2016); National Institute of Health and Nutrition (2013-2014)
• Principal Investigator: OSAKA Toshimasa 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 基礎栄養研究部, 研究員 (30152101)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 体温調節 / 延髄傍錐体路領域 / GABA / 皮膚交感神経系プレモーターニューロン

Outline of Final Research Achievements

Unilateral microinjection of GABA into the rostral parapyramidal region (PPy) of the medulla oblongata elicited a prompt increase in tail skin temperature (Ts) and decreases in the body core temperature, and oxygen consumption rate in urethane-chloralose-anesthetized, neuromuscularly blocked, artificially ventilated rats. Next, when the GABA receptor blocker bicuculline methiodide (BMI) was microinjected bilaterally into the PPy, no direct effect on Ts was seen. However, pretreatment of the PPy with BMI, but not vehicle saline, greatly attenuated the hypothermic responses evoked by hypoxic (10%O2-90%N2, 5 min) ventilation, by bilateral microinjections of glutamate into the lateral preoptic area, or by systemic administration of 2-deoxy-d-glucose, an inhibitor of glucose utilization. The results suggest that hypothermia induced by above mentioned situations was mediated, at least in part, by the activation of GABA receptors in the PPy.

Free Research Field

生理学