Construction of the multifunctional nanoparticle for malignant melanoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460328
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Chiba University
• Principal Investigator: SUGANAMI Akiko 千葉大学, 医学(系)研究科(研究院), 助教 (10527922)
• Co-Investigator(Renkei-kenkyūsha): TAMURA Yutaka 千葉大学, 大学院医学研究院, 准教授 (50263174) ; TOYOTA Taro 東京大学, 大学院総合文化研究科, 准教授 (80422377)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 悪性黒色腫 / RNA医薬 / ペプチド医薬 / 近赤外光治療機器 / 光免疫誘導

Outline of Final Research Achievements

We have previously constructed the liposomally formulated phospholipid-conjugated indocyanine green (ICG), designated by LP-iDOPE, as a clinically translatable nanoparticle for tumors. In addition, we have developed the LED device with near-infrared (NIR) light that enable ICG fluorophore of LP-iDOPE to produce singlet oxygen which triggered the induction of CTL to tumor tissues as photo-induced immunotherapy.
Melanoma is one of the most aggressive skin cancers with high multidrug resistance and low survival rate. To evaluate LP-iDOPE as a multifunctional nanoparticle for the promising melanoma therapy, we attached two specific functions on LP-iDOPE, the peptide targeting the transcription factor MITF and the RNA aptamer targeting the biomarker of melanoma stem cell.

Free Research Field

生命情報科学