2015 Fiscal Year Final Research Report
Pathophysiological roles of AM-RAMP2 system in adipose tissues
| Project/Area Number |
25460330
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 生理活性物質 / 脂肪細胞 |
|---|
| Outline of Final Research Achievements |
Adrenomedullin(AM) is a vasodilatory peptide, which possess various bioactivities. AM and receptor activity-modifying protein 2 (RAMP2) are highly expresses in adipose tissues. In this study, to clarify the pathophysiological roles of AM-RAMP2 system in adipose tissues, we analyzed adipocyte-specific RAMP2 knockout mice. We showed that AM-RAMP2 system regulates energy metabolism and adipocyte differentiation between white adipose tissue and brown adipose tissue.
|
| Free Research Field |
代謝学
|
