2015 Fiscal Year Final Research Report
Elucidation of molecular pathomechanism of TDP-43 and FUS-linked ALS
| Project/Area Number |
25460342
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 筋萎縮性側索硬化症 / 神経細胞死 / TDP-43 / FUS / hnRNP |
|---|
| Outline of Final Research Achievements |
Amyotrophic lateral sclerosis (ALS) is an incurable adult-onset motor neuron degenerative disease, characterized by loss of both upper and lower motor neurons.
In this study, we focused on RNA-biniding proteins (RBPs) including TDP-43, FUS, and hnRNPA1 that are thought to be closely linked to the pathogenesis of ALS. We elucidated the molecular pathomechanisms underlying RBPs-induced neuronal cell death.
We have plans to develop therapeutic drugs for ALS that target RBPs-related neuronal cell death.
|
| Free Research Field |
神経科学
|
