2015 Fiscal Year Final Research Report
Analysis of onset mechanisms of a sphingosine 1-phosphate receptor modulator fingolomod-induced atrioventricular conduction block
| Project/Area Number |
25460344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | スフィンゴシン1-リン酸 / フィンゴリモド / 房室伝導ブロック / Giタンパク |
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| Outline of Final Research Achievements |
Since a sphingosine 1-phosphate receptor modulator fingolimod induced complete atrioventricular conduction block, onset mechanisms of fingolomod-induced atrioventricular conduction block were analyzed. Fingolimod suppressed adenylate cyclase activity of the membrane preparation made of atrioventricular nodal tissue of guinea-pig hearts, suggesting that fingolomod may stimulate Gi protein in the atrioventricular node. Thus, S1P receptor subtype 1 in the atrioventricular node could be one of the candidates for fingolimod-induced atrioventricular conduction block.
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| Free Research Field |
循環薬理学
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