2015 Fiscal Year Final Research Report
Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.
| Project/Area Number |
25460346
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Kondo Kazunao 藤田保健衛生大学, 医学部, 教授 (90270983)
Ichinose Hiroshi 東京工業大学, 大学院生命理工学研究科, 教授 (90192492)
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| Research Collaborator |
Ihira Noriko 藤田保健衛生大学, 医学部, 研究補助員
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | テトラヒドロビオプテリン / ドパミン / 一酸化窒素 / 高血圧 / 交感神経 / 持続勃起症 |
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| Outline of Final Research Achievements |
We identified some candidate genes which are influenced by tetrahydrobiopterin (BH4) during early developmental stage after birth. Dihydrobiopterin (BH2) content in the plasma of Qdpr-/- mice much increased. However, BH2/BH4 ratio in the aorta of Qdpr-/- mice was only 1.6 times higher, for BH4 content in the aorta also increased. The aortic rings from Qdpr-/- mice were relaxed by acetylcholine as much as those from wild type ones. Spr-/-mice suffered from unstable hypertension and bradycardia, and male Spr-/- mice showed serious priapism at high incidence. Biopterin- and monoamine-content were remarkably reduced in the tissue. Aortic ring of Spr-/- mice was supersensitive to alpha1 agonist, and relaxation response to acetylcholine decreased.
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| Free Research Field |
薬理学
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