Role of ion transporter localization and activity in myogenic responses

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Fukuoka University
• Principal Investigator: KITA SATOMI 福岡大学, 医学部, 准教授 (10461500)
• Co-Investigator(Kenkyū-buntansha): FUJII Makoto 福岡大学, 医学部, 助教 (30398086) ; GOTOH Yusuke 福岡大学, 医学部, 助教 (90609489)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 筋原性収縮 / イオン輸送 / リン脂質

Outline of Final Research Achievements

Myogenic tone have been known to plays important role for regulation of the peripheral artery resistance and blood stream in heart, kidney and brain, but the molecular mechanism still unclear. To claryfy the role of NCX1 expression and localization in myogenic tone, we generated smooth muscle spesific NCX1-EGFP transgenic mice. We found that myogenic responses were attenuated in PIP5K-beta knockout mice. Furthermore, gene expression level of NCX1 was decreased in PIP5K-beta knockout mice, compared with wild-type mice, suggesting that regulation of NCX1 activity by PIP2 is involved in myogenic tone.

Free Research Field

薬理学