Elucidation of the phospho-dependent mechanisms of apoptosis induction

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Tohoku University (2014-2015); Gunma University (2013)
• Principal Investigator: Noguchi Takuya 東北大学, 薬学研究科(研究院), 准教授 (20431893)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Apoptosis / Kinase / FasL

Outline of Final Research Achievements

We identified eight candidate kinases whose down-regulation protected against Fas ligand-induced apoptosis. At first, we established knockout cells lacking each kinase, and examined the requirement for apoptosis and their functions in apoptosis. Notably we have demonstrated that STK11participates in the control of death receptor-mediated signals through phosphorylation of CYLD, a deubiquitinating enzyme that regulates both pro- and anti-apoptotic activities of the death receptors via targeting RIPK1. These results reveal STK11 as a novel modulator of pro- and anti-apoptotic signals emanating from the death receptors.

Free Research Field

細胞生物学