Regulation of intestinal immunity by a gastrointestinal epithelial-specific protein tyrosine phosphatase and its pathological role.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460366
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kobe University
• Principal Investigator: Murata Yoji 神戸大学, 医学(系)研究科(研究院), 准教授 (60400735)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: チロシンホスファターゼ / 腸上皮細胞 / 腸管免疫 / 腸炎 / がん

Outline of Final Research Achievements

In this study, I investigated molecular mechanisms, by which SAP-1, a gastrointestinal epithelial-specific protein tyrosine phosphatase, and its putative substrate p100 in intestinal epithelial cells modulate intestinal immunity. The pathological roles of these molecules were also examined. I found that ablation of p100 as well as that of SAP-1 markedly increased the severity of colitis in IL-10-deficeint mice. I also found that p90 was another putative substrate for SAP-1 at the microvilli of intestinal epithelial cells. Therefore, SAP-1, through de-phopshorylation of p100 and p90, is likely to contribute to the modulation of intestinal immunity by intestinal epithelial cells.

Free Research Field

生化学・分子生物学