2015 Fiscal Year Final Research Report
Characterization and application for regenerative medicine of bone marrow pluripotent stem cells
| Project/Area Number |
25460373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | National Institute of Infectious Diseases (2014-2015)
Keio University (2013) |
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Principal Investigator |
Matsuoka Sahoko 国立感染症研究所, その他部局等, その他 (20317340)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 間葉性幹細胞 |
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| Outline of Final Research Achievements |
We isolated SSEA-1dim Sca-1neg N-Cadherinpos undifferentiated cell population derived from endosteal mesenchymal cells in mouse bone marrow by a fluorescence activated cell sorter using pluripotent stem cell markers. Comprehensive gene expression analysis demonstrated that these cells show ES cell-like gene expression patterns. These cells were not increased under ES cell culture condition ande seemed to be domant in steady state. We examine the cell proliferation and differentiation under stress such as irradiation or drugs.
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| Free Research Field |
血液学
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