2015 Fiscal Year Final Research Report
Physiological and pathological roles of a new lipid mediator, 12-HHT
| Project/Area Number |
25460374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Juntendo University |
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Principal Investigator |
OKUNO TOSHIAKI 順天堂大学, 医学(系)研究科(研究院), 准教授 (60361466)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 12-HHT / BLT2 / 脂肪酸 / エイコサノイド / ゼブラフィッシュ / 皮膚 / バリア / 創傷治癒 |
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| Outline of Final Research Achievements |
We identified one BLT1-type receptor and two BLT2-type receptors in zebrafish and revealed that the LTB4-BLT1 axis is involved in epiboly in zebrafish development.
We also revealed that the 12-HHT/BLT2 axis accelerated wound closure through the enhanced migration of epidermal keratinocytes.
We identified that the 12-HHT/BLT2 axis enhanced epidermal barrier function by increasing CLDN4 expression via Gi protein-p38 MAPK pathway.
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| Free Research Field |
脂質生化学
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