Analysis of mechanism of serine protease activation by membrane-type matrix metalloproteinase

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460382
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: Sato Hiroshi 金沢大学, がん進展制御研究所, 教授 (00115239)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん転移 / マトリックスメタロプロテアーゼ / MT1-MMP / HAI-1 / セリンプロテアーゼ / MMP-9

Outline of Final Research Achievements

Membrane-Type Matrix Metalloproteinase (MT1-MMP) was shown to cleave and inactivate membrane-type serine protease inhibitor HAI-1(Hepatocyte Growth Factor Inhibitor-1), which subsequently induced activation of matriptase. Activated matriptase induced further activation of serine protease cascade, which was named “Protease Storm”. Protease storm caused Epithelial-Mesenchymal Transition (EMT) in cancer cells. These results indicate that MT1-MMP contributes to malignant transformation of cancer cells by triggering protease activation cascade.

Free Research Field

腫瘍分子生物学