2015 Fiscal Year Final Research Report
Analysis of mechanism of serine protease activation by membrane-type matrix metalloproteinase
Project/Area Number |
25460382
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Kanazawa University |
Principal Investigator |
Sato Hiroshi 金沢大学, がん進展制御研究所, 教授 (00115239)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | がん転移 / マトリックスメタロプロテアーゼ / MT1-MMP / HAI-1 / セリンプロテアーゼ / MMP-9 |
Outline of Final Research Achievements |
Membrane-Type Matrix Metalloproteinase (MT1-MMP) was shown to cleave and inactivate membrane-type serine protease inhibitor HAI-1(Hepatocyte Growth Factor Inhibitor-1), which subsequently induced activation of matriptase. Activated matriptase induced further activation of serine protease cascade, which was named “Protease Storm”. Protease storm caused Epithelial-Mesenchymal Transition (EMT) in cancer cells. These results indicate that MT1-MMP contributes to malignant transformation of cancer cells by triggering protease activation cascade.
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Free Research Field |
腫瘍分子生物学
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