Elucidation of signals and metabolic bases that regulate functions of plasma membrane microdomains

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460385
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo (2016); Nagoya University (2013-2015)
• Principal Investigator: Yamauchi Yoshio 東京大学, 大学院農学生命科学研究科(農学部), 特任准教授 (00444878)
• Co-Investigator(Renkei-kenkyūsha): UESUGI Motonari 京都大学, 物質-細胞統合システム拠点, 教授 (10402926)
• Research Collaborator: CHANG Ta-Yuan Chang Geisel School of Medicine at Dartmouth, 教授
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 膜ドメイン / 脂質代謝 / シグナル / がん

Outline of Final Research Achievements

Plasma membrane microdomains (lipid rafts) play essential roles in cellular functions and in malignant properties of cancer cells. It is therefore important for developing therapeutic strategies for malignant tumor, to understand how functionality of lipid rafts is preserved in cancer cells. In this study, we showed that SREBP, a transcriptional factor that regulates lipid metabolism, functions as a crucial factor maintaining integrity of lipid rafts in and malignant properties of cancer cells. Furthermore, we revealed regulatory mechanisms that control the activation of SREBP at the endoplasmic reticulum.

Free Research Field

生化学