Novel molecular targeting strategy against chromosomal maintenance factor FANCJ

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460390
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kyushu University
• Principal Investigator: KITAO HIROYUKI 九州大学, 医学(系)研究科(研究院), 准教授 (30368617)
• Co-Investigator(Kenkyū-buntansha): IIMORI Makoto 九州大学, 医学研究院, 助教 (20546460) ; MORITA Masaru 独立行政法人国立病院機構(九州がんセンター), その他部局等, 消化器外科部長 (30294937) ; OKI Eiji 九州大学, 大学病院, 講師 (70380392)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 染色体不安定性 / 抗がん剤 / FANCJ

Outline of Final Research Achievements

Chromosomal stability is ensured by the accurate DNA replication and the equal segregation of duplicated chromosomes. In tumors, such mechanism is often disrupted and chromosomal instability, which is represented as high mutation frequency and abnormal number of chromosomes, emerges. In our previous study, we reported that the colorectal cancer patients who exhibited higher expression of chromosomal stability factor FANCJ in their tumors tended to be poor prognosis and less effective with 5-FU-based chemotherapy (Nakanishi et al. Ann Surg Oncol 2012). In this project, we drugged the underlying molecular mechanism of the association between FANCJ expression and 5-FU resistance experimentally and found that the physical interaction between FANCJ and key partners are critical.

Free Research Field

分子細胞生物学