2016 Fiscal Year Final Research Report
Role of glycosylation on the functions of cardiac calcium regulating proteins and ion channels
| Project/Area Number |
25460397
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
Asahi Michio 大阪医科大学, 医学部, 教授 (10397614)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Azuma Naoto 大阪医科大学, 医学部, 教授 (40231914)
|
|---|
| Research Collaborator |
Ii Masaaki
Nakagawa Takatoshi
Moriwaki Kazumasa
Ai Tomohiko
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | O-GlcNAc修飾 / O-GlcNAc転移酵素 / 大動脈縮窄術 / NFAT / GSK3β / ホスホランバン / STIM-1 |
|---|
| Outline of Final Research Achievements |
The cardiac function in diabetic patients is often reduced, although coronary areteries are intact. Metabolic abnormality of cardiac muscle might be involved in the etiology, and the pathologic condition is named diabetic cardiomyopathy. However, the mechanism was not fully understood. In this study, we focused on O-GlcNAcylation which was augmented in diabetes, and examined how the modification affected the cardiac function. As a result, we found that some proteins related to cardiac function were inactivated by O-GlcNAcylation. The downregulation of cardiac function by O-GlcNAcylation might be one of the cause of diabetic cardiomyopathy. In the future, based on this basic research, I would like to connect it with new drug development.
|
| Free Research Field |
循環薬理学
|
