2015 Fiscal Year Final Research Report
Prognostic significance of immune microenvironment in cancer.
| Project/Area Number |
25460412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 癌免疫微小環境 / 免疫組織化学 / 画像解析 / 生存解析 |
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| Outline of Final Research Achievements |
We examined the association between immune-microenvironment status and prognosis in upper and lower tract urothelial carcinoma and gastric carcinoma. In upper and lower tract urothelial carcinoma, high-infiltration of CD204-positive tumor-associated macrophages was significantly correlated with poorer patient outcome. In addition, CD204/CD8 ratio was a strong prognostic factor in bladder cancer. High-infiltration of CD204-positive macrophages was also significantly correlated with poorer patient outcome in gastric carcinoma. In conclusion, we have found that immune-microenvironment status, especially the density of CD204-positive macrophages, may serve as a useful prognostic factor in multiple types of cancer.
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| Free Research Field |
人体病理学
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