Study on the pathological role of estrogens in colorectal cancer.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460429
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Toho University (2015-2016); Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2013-2014)
• Principal Investigator: HONMA Naoko 東邦大学, 医学部, 准教授 (70321875)
• Co-Investigator(Renkei-kenkyūsha): ARAI Tomio 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019) ; YAMAMOTO Noriko 公益財団法人がん研究会, がん研究所 病理部, 主任研究員 (10280629) ; ISHIKAWA Yuichi 公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975) ; MURAMATSU Masaaki 東京医科歯科大学, 難治疾患研究所, 教授 (50230008) ; HARADA Nobuhiro 藤田保健衛生大学, 医学部, 教授 (00189705)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 大腸癌 / エストロゲン / 女性 / 年齢 / 閉経後

Outline of Final Research Achievements

Characteristics of colorectal cancer (CRC) are affected by aging, sex, and locus, Estrogens have been suggested to play a suppressive role in CRC, though controversies exist. We focused on postmenopausal colon cancers, and comprehensively examined estrogen-related factors using surgically resected materials, The relation of estrogen concentration or estrogen receptor-beta expression in cancerous tissue vs. non-cancerous tissue was distinctly different according to patients' age (>= 70y/o or < 70 y/o) and locus (left-sided or right-sided), suggesting that pathobiological role of estrogens in colon cancer is different according to patients' age and tumor locus.

Free Research Field

人体病理