System construction of progression risk assessments of early to advanced gastric carcinomas by genomic copy-number profile

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460454
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Sugihara Hiroyuki 滋賀医科大学, 医学部, 教授 (30171169)
• Co-Investigator(Renkei-kenkyūsha): Mukaisho Ken-ichi 滋賀医科大学, 医学部, 准教授 (50343223) ; Nakayama Takahisa 滋賀医科大学, 医学部, 助教 (90632315) ; Yamamoto Hiroto 滋賀医科大学, 医学部, 特任助教 (30610654)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胃癌 / アレイCGH解析 / 階層的クラスタリング / 定量的PCR / 進展リスク / 転移リスク

Outline of Final Research Achievements

Using basically irreversible genomic copy-number changes, we aimed to examine continuity and discontinuity of genetic lineages between early and advanced gastric carcinomas (GCs) to enable individual early stage lesions to be treated appropriately on the basis of progression risk assessments. The genomic copy-number profile of each tumor sample, detected by array-based comparative genomic hybridization, was classified by hierarchical clustering. Our data obtained suggested that ① early undifferentiated-type GCs inevitably progress to advanced stages; ② in differentiated-type GCs, part of early GCs and large part of non-invasive neoplasms never become advanced; ③ the risk of lymph node metastasis is determined stochastically and difficult to predict in earlier stages. We also extracted some genes, such as RXRB, that are useful in the prediction of progression risk.

Free Research Field

人体病理学へのゲノム科学の応用