Study of a novel therapy of the triple-negative breast cancers (TNBC) -based on DNA copy number aberration.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Yamaguchi University
• Principal Investigator: KONOD-FURUYA Tomoko (古屋智子) 山口大学, 医学(系)研究科(研究院), 講師 (30379979)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: トリプルネガティブ乳癌 / ゲノム異常 / イメージサイトメトリー / 細胞周期

Outline of Final Research Achievements

Triple-negative breast cancer (TNBC) is refractory breast cancer because specific therapies are not establieshed. We focused on interferon gamma (IFN-gamma) which is located in the genomic loss region exclusively in TNBC and investigated the effect of INF-gamma on TNBC in vitro. Several cell lines derived from TNBC were inhibited cell proliferation by IFN-gamma. However, one cell line from TNBC was not inhibited. INF-gamma altered the cell cycle and the expression levels of some cell-cylce associated proteins in TNBC cell lines. The pattens of change in the expression leves of theses proteins were different in cell lines. This suggest that IFN-gamma arrest cell cycles via several pathway in TNBC.

Free Research Field

人体病理学