2016 Fiscal Year Final Research Report
Study of a novel therapy of the triple-negative breast cancers (TNBC) -based on DNA copy number aberration.
Project/Area Number |
25460458
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Yamaguchi University |
Principal Investigator |
KONOD-FURUYA Tomoko (古屋智子) 山口大学, 医学(系)研究科(研究院), 講師 (30379979)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | トリプルネガティブ乳癌 / ゲノム異常 / イメージサイトメトリー / 細胞周期 |
Outline of Final Research Achievements |
Triple-negative breast cancer (TNBC) is refractory breast cancer because specific therapies are not establieshed. We focused on interferon gamma (IFN-gamma) which is located in the genomic loss region exclusively in TNBC and investigated the effect of INF-gamma on TNBC in vitro. Several cell lines derived from TNBC were inhibited cell proliferation by IFN-gamma. However, one cell line from TNBC was not inhibited. INF-gamma altered the cell cycle and the expression levels of some cell-cylce associated proteins in TNBC cell lines. The pattens of change in the expression leves of theses proteins were different in cell lines. This suggest that IFN-gamma arrest cell cycles via several pathway in TNBC.
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Free Research Field |
人体病理学
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