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2015 Fiscal Year Final Research Report

Distinct pathogenic properties in A20-F127C SNPs between European and Japanese populations

Research Project

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Project/Area Number 25460461
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionOita University

Principal Investigator

IHA Hidekatsu  大分大学, 医学部, 准教授 (50242631)

Project Period (FY) 2013-04-01 – 2016-03-31
KeywordsTAX1BP1 / TNFAIP3/A20 / inflammatory diseases / SNPs / SLE
Outline of Final Research Achievements

An extensive look into TNFAIP3/A20 exon 3 domain of 582 patient’s suffering from inflammatory diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren syndrome (SjS) and others revealed the presence of an F127C mutation which has identified in the same disease populations abroad. While significant association to SLE, this F127C SNP was not found in RA or SjS patients in Oita.
The odds ratio (OR) of F127C SNP in patients versus healthy subjects was 2.08 in Oita and OR was 1.37 in European population. In the case of SLE patients the OR was 6.25 and it was 4.77 fold higher than those in Europa (OR: 1.31). These findings suggest F127C occurrence could play an important role in inflammatory disease onset, specifically in SLE, in the Japanese population.

Free Research Field

免疫学

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Published: 2017-05-10  

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