Expression of long noncoding RNA in lung adenocarcinoma

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Japanese Foundation for Cancer Research (2014-2016); 独立行政法人国立国際医療研究センター (2013)
• Principal Investigator: IIZUKA Toshihiko 公益財団法人がん研究会, がん研究所 病理部, 研究員 (80323707)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 肺癌 / long noncoding RNA

Outline of Final Research Achievements

Long noncoding RNA (lncRNA) HOTAIR epigenetically regulates the expression of various genes through recruiting the polycomb protein EZH2 to the target genome locus. We examined the expression of HOTAIR and EZH2 in 83 resected cases of lung adenocarcinoma by qRT-PCR and immunohistochemistry. We found that the expression of both genes were associated with the histological grade of adenocarcinoma and were associated with prognosis. Furthermore, we found that more accurate prediction of prognosis is possible by measuring the expression of both genes.

Free Research Field

病理診断