Mechanisms of radiation-induced thyroid cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
• Principal Investigator: Ito Masahiro 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 機能形態研究部, 教授 (30184691)
• Co-Investigator(Kenkyū-buntansha): NAKASHIMA Masahiro 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50284683)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: チェルノブイリ / 放射線被曝 / 小児甲状腺癌 / 低ヨード / 福島原発事故

Outline of Final Research Achievements

By the end of this research period 5021 cases have been registered in the Chernobyl tissue bank. Using spontaneous adult papillary thyroid carcinomas from Japan and the Chernobyl area, the histopathological examination was performed. As a result both pediatric and adult papillary carcinomas in the Chernobyl area showed higher percentages of solid component, suggesting that the low-dietary iodine environment and genetic background bring differences in morphogenesis and radiation sensitivity.
And juvenile thyroid cancer cases of Fukushima showed commonly classic type papillary carcinoma and BRAF point mutation. These results are different from Chernobyl cases, which show high frequencies of solid component and ret/PTC rearrangement.

Free Research Field

病理学