2015 Fiscal Year Final Research Report
Roles of Tsc-22 family proteins in cell proliferation, differentiation and tumorigenesis
| Project/Area Number |
25460472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | THG-1 / 扁平上皮がん / EGF / Ras |
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| Outline of Final Research Achievements |
Carcinoma cells exhibit a high level of robustness against environmental stresses, metabolic disorders and therapeutic efforts. Here, we provide a novel mechanism of the squamous cell carcinoma development by THG-1, a Tsc-22 family protein. THG-1 localized in the basal layer of normal squamous epithelium and overexpressed in squamous cell carcinomas. THG-1 knockdown suppresses the cell proliferation, invasiveness and tumorigenicity. THG-1 is phosphorylated by the receptor tyrosine kinase-Ras-ERK pathway, which is required for
oncogenic Ras-mediated tumorigenesis. Furthermore, THG-1 interacts with several factors that regulate the cell proliferation, cytoprotection, metabolism and microenvironment. Our results highlight the pivotal role of THG-1 as a novel regulator of tumorigenssis under the oncogenic signaling pathway.
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| Free Research Field |
がんの生物学
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