2015 Fiscal Year Final Research Report
A study for local invasion promoting factor of esophageal squamous cell carcinoma
Project/Area Number |
25460474
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Kochi University |
Principal Investigator |
Naganuma Seiji 高知大学, 教育研究部医療学系基礎医学部門, 助教 (50452123)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | 食道扁平上皮癌 / 浸潤転移 / Notchシグナリング / EMT |
Outline of Final Research Achievements |
In invasive fronts of esophageal squamous cell carcinoma (ESCC), there are some tumor cells displaying EMT-like morphology, and they show not only ZEB1, an EMT marker, but also nuclear expression of Notch1 (ICN1). We demonstrated that a specific expression pattern of ICN1 correlates significantly with poorer prognosis of ESCC patients, and also associated with tumor depth, lymphatic and venous invasion, and lymph node and distant metastasis. The positive rate of this ICN1 expression is significantly higher in ESCC samples from patients who have undergone chemoradiation therapy and local recurrence lesions, suggesting that it could be an important marker of bad prognosis, recurrence, and metastasis of ESCC.
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Free Research Field |
医歯薬学
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