2015 Fiscal Year Final Research Report
Study on the mechanism underlying the centrosome amplification induced by DNA repair abnormality in cancer
Project/Area Number |
25460476
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | Centrosome amplification / DNA repair / SASS6 / SGOL1 / NEIL / MUTYH / STK15 |
Outline of Final Research Achievements |
The followings were revealed in this study: (1) Abnormality of a part of DNA repair gene is associated with centrosome amplification. (2) SASS6 overexpression is associated with centrosome amplification, mitotic chromosomal abnormalities, chromosome instability, and a poor prognosis in patients with colorectal cancer. (3) Overexpression of a SGOL1 splicing variant type B (SGOL1-B) is associated with centrosome amplification, abnormal mitosis, and resistance to taxane in non-small cell lung cancer. (4) Amplification of STK15(AURAK)gene which is involved in the centrosome regulation is a predictor of a poor prognosis in patients with gastric cancer. (5) Abnormal expressions of DNA glycosylase genes NEIL1, NEIL2, and NEIL3 are associated with somatic mutation loads in human cancer.
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Free Research Field |
腫瘍病理学
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