Analyses of lyzophosphatigic signaling for dementia and changing the signaling of neural stem cell for treatment

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460479
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Okinawa National College of Technology (2015); University of the Ryukyus (2013-2014)
• Principal Investigator: CHIBA SHUNMEI 沖縄工業高等専門学校, 生物資源工学科, 特命教授 (20367361)
• Co-Investigator(Kenkyū-buntansha): TANIGUCHI Taizo 姫路獨協大学, 薬学部, 教授 (70346253)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 認知症 / 神経幹細胞 / リゾリン脂質 / 神経再生 / 治療

Outline of Final Research Achievements

We analysed the effect of LPA signaling for an dementia model of mice. Homozygous transgenic mice were mated, and bred for in vivo experiment. 6 monthes mice started showing a memory disturbance, and the hippocampus of 12 monthes mice was degenerated. The extracted neural stem cells from mice were not expandale as well, but LPA improved proliferation. Ki16425, as a inhibitor of LPA1 signaling, could improved the phenomenon of dimentia in 12 monthes model mice. Though, we were now analysing the movement and changing of neural stem cells in the brain, LPA signaling, especially in LPA1 inhibiton could be a high-potential drug for dementia, like as Alzheimer`s.

Free Research Field

神経再生