Research on mechanisms of multistep tumorigenesis by TLS-CHOP chimeric oncoprotein and its clinical application

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460480
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Wakayama Medical University
• Principal Investigator: OIKAWA KOSUKE 和歌山県立医科大学, 医学部, 講師 (70348803)
• Co-Investigator(Kenkyū-buntansha): MURAGAKI Yasuteru 和歌山県立医科大学, 医学部, 教授 (40190904)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: キメラ遺伝子 / 粘液型脂肪肉腫

Outline of Final Research Achievements

The TLS-CHOP gene specifically seen in myxoid liposarcoma is a chimeric oncogene that is derived from chromosomal translocation. The gene product functions as a transcription factor, and is thought to be involved in tumorigenesis and tumor cell growth. Its detailed molecular mechanism is, however, still unclear. Previous studies have shown that TLS-CHOP induces expression of a transforming-related protein DOL54 and represses expression of an anti-tumor cytokine IL-24. In this study, we have revealed that overrexpression of DOL54 represses IL-24 expression, contributing to maintenance of tumor cell growth. Furthermore, we have identified several molecules related to growth of myxoid liposarcoma cells, and are investigating their molecular functions now at present.

Free Research Field

医歯薬学