2015 Fiscal Year Final Research Report
Research on mechanisms of multistep tumorigenesis by TLS-CHOP chimeric oncoprotein and its clinical application
Project/Area Number |
25460480
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Wakayama Medical University |
Principal Investigator |
OIKAWA KOSUKE 和歌山県立医科大学, 医学部, 講師 (70348803)
|
Co-Investigator(Kenkyū-buntansha) |
MURAGAKI Yasuteru 和歌山県立医科大学, 医学部, 教授 (40190904)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | キメラ遺伝子 / 粘液型脂肪肉腫 |
Outline of Final Research Achievements |
The TLS-CHOP gene specifically seen in myxoid liposarcoma is a chimeric oncogene that is derived from chromosomal translocation. The gene product functions as a transcription factor, and is thought to be involved in tumorigenesis and tumor cell growth. Its detailed molecular mechanism is, however, still unclear. Previous studies have shown that TLS-CHOP induces expression of a transforming-related protein DOL54 and represses expression of an anti-tumor cytokine IL-24. In this study, we have revealed that overrexpression of DOL54 represses IL-24 expression, contributing to maintenance of tumor cell growth. Furthermore, we have identified several molecules related to growth of myxoid liposarcoma cells, and are investigating their molecular functions now at present.
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Free Research Field |
医歯薬学
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