2015 Fiscal Year Final Research Report
The role of Semaphorin 4D in Rheumatoid Arthritis
| Project/Area Number |
25460495
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Osaka University |
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Principal Investigator |
Ogata Atsushi 大阪大学, 医学(系)研究科(研究院), 招へい教授 (90309451)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Toshio 大阪大学, 医学系研究科, 寄付講座教授 (40273651)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMANOGOU Atsushi 大阪大学, 医学系研究科, 教授 (10294125)
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| Research Collaborator |
YOSHIDA Yuji
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 関節リウマチ / セマフォリン |
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| Outline of Final Research Achievements |
It has been reported that semaphorine 4D (Sema4D) is a suppressor of osteogenesis. It may be involved in the pathogenesis of rheumatoid arthritis which presents bone erosion and destruction. According our study, the sera and joint fluids contained higher level of protease ADAMTS-4, and this made shedding of Sema4D from the membrane of CD3+ and CD14+ mononuclear cells resulting in augmentation of Sema4D level in sera and joint fluid. Because arthritis model mice which were injected anti-Sema4D antibody have presented suppression of arthritis, augmented Sema4D may induce bone erosion and destruction in the patients with rheumatoid arthritis.
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| Free Research Field |
臨床免疫学
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