2015 Fiscal Year Final Research Report
The significance of macrophage activation in tumor development and inflammation
| Project/Area Number |
25460497
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | マクロファージ / CD163 / 炎症 / 腫瘍 |
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| Outline of Final Research Achievements |
CD163 is detected specifically on macrophages, and is known to be up-regulated in cancers, sepsis, and metabolic syndrome. Th2-type cytokine preferentially induce CD163 on macrophages, and therefore considered to be a marker for M2 phenotype. In human cancer, high density of CD163-positive macrophages in tumor microenvironment was well correlated to worse clinical prognosis, and these findings indicate the significant involvement of CD163 in protumor activation of macrophages. In addition to cancers, CD163 was up-regulated in septic shock and metabolic syndrome. However, the detail mechanisms of CD163-related macrophage activation have still never been uncovered. In the present study, we tried to investigate the significance of CD163-related signals in murine disease models.
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| Free Research Field |
実験病理学
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