2015 Fiscal Year Final Research Report
Retroviral immune evasion
| Project/Area Number |
25460507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Masaaki 近畿大学, 医学部, 教授 (60167757)
TAKAMURA Shiki 近畿大学, 医学部, 医学部講師 (90528564)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | レトロウイルス / TLR7 / B細胞 / 免疫回避 / ウイルス中和抗体 / 白血病 |
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| Outline of Final Research Achievements |
TLR7 is expressed on several types of cell including dendritic cells and B cells. In this study, we analyzed roles of B cell-intrinsic TLR7 signaling on humoral immune responses against retrovirus infection. We found that primary B cell responses to retroviral infection required B cell-intrinsic TLR7 signaling, whereas preexisting virus-specific memory Th cells elicited the B cell responses without TLR7 signaling. Moreover, we showed that in the presence of virus-specific memory Th cells, the lack of TLR7 signaling in B cells facilitated anti-virus antibody responses and led to delayed progression of virus-induced leukemia.
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| Free Research Field |
感染制御
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