2016 Fiscal Year Final Research Report
Cellular and molecular mechanisms of protection against reinfection with Vampirolepis nana eggs and expulsion of adult worms
| Project/Area Number |
25460520
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 小形条虫 / 感染防御 / 自然免疫 / Ｔ細胞 / ＩｇＥ / マスト細胞 / 獲得免疫 |
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| Outline of Final Research Achievements |
This study examined the mechanisms of protection against reinfection with Vampirolepis nana eggs and expulsion of adult worms in mice. Protection against reinfection with eggs was strongly induced by innate immunity under co-existence of CD4-positive abT cells and gdT cells, and acquired immunity through CD4-positive abT cells. Expulsion of V.nana adults from the intestine after primary and secondary infection depended on antibody and mast cells with different mechanisms.
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| Free Research Field |
寄生虫学
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