A role of Loeffler syndrome in Strongyloides-infected mice.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460521
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Hyogo Medical University
• Principal Investigator: YASUDA Koubun 兵庫医科大学, 医学部, 講師 (50333539)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 自然免疫 / 寄生虫免疫 / 自然リンパ球 / 好酸球性肺炎

Outline of Final Research Achievements

When host animals develop lung eosinophilic inflammation by Strongyloides(Sv) infection, the number of group 2 innate lymphoid cells(ILC2) also increase in the lung dependently on IL-33, and sustain even after the expulsion of parasite is completed. If the host infected secondary with other species of nematode(Nb), the residual ILC2s promptly proliferate and produce IL-5 and IL-13 to accumulate and activate eosinophils in the lung, which make the hosts resistant against Nb. This study demonstrates Sv-infected hosts acquire an antigen-nonspecific resistance, which is a benefit for the host animals to live in an area where multiple parasites spread.

Free Research Field

免疫学