2015 Fiscal Year Final Research Report
The comprehensive study of bacterial IpaH family effectors
| Project/Area Number |
25460527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ashida Hiroshi 東京大学, 医科学研究所, 特任准教授 (10535115)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 赤痢菌 / エフェクター / 自然免疫 |
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| Outline of Final Research Achievements |
In this study, we tried to identify the mechanism of IpaH family effector proteins, which have E3 ubiquitin ligase activity, in Shigella infection. One of IpaH family protein, IpaH0722 inhibits NF-κB activity in its E3 ubiquitin ligase dependent manner. As a result, we found that IpaH0722 inhibits phagosome disruption mediated PKC-NF-κB activation by targeting TRAF2 for ubiquitination and proteasome-dependent degradation, thereby downregulating host inflammatory responses.In addition, another IpaH family protein, IpaH5 inhibits DNA dependent type I interferon signaling by targeting signaling factor X for ubiquitination.
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| Free Research Field |
細菌学
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