2015 Fiscal Year Final Research Report
Virulence mechanism of atopic dermatitis-related S. aureus
| Project/Area Number |
25460533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
Sugai Motoyuki 広島大学, 医歯薬保健学研究院(歯), 教授 (10201568)
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| Co-Investigator(Kenkyū-buntansha) |
HISATSUNE JUNZO 広島大学, 大学院医歯薬保健学研究院, 助教 (40513180)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | S. aureus |
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| Outline of Final Research Achievements |
Comparison of adherent bacterial number of AD-derived S. aureus and non AD-derived S. aureus to the skin of FKO mouse indicated AD-derived S. aureus adhered more to the skin. We established an expression plasmid carrying sarA P1 promoter and RBS sequence of sod gene hooked with gfp and transformed AD-deribed S. aureus. We also finished complete DNA sequencing of TF3378 (AD-derived) genome. Comparison with other finished sequences of S. aureus revealed some potential virulence-related genes specific to AD-derived S. aureus.
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| Free Research Field |
Bacteriology
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