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2015 Fiscal Year Final Research Report

Development of new steroidal bactericidal substances for Helicobacter pylori

Research Project

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Project/Area Number 25460544
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionJichi Medical University

Principal Investigator

Shimomura Hirofumi  自治医科大学, 医学部, 准教授 (80348002)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsピロリ菌 / ステロイド / 不飽和脂肪酸 / 飽和脂肪酸 / グリセロリン脂質 / 極狭域スペクトル抗菌薬 / 狭域スペクトル抗癌剤
Outline of Final Research Achievements

This study demonstrated that new progesterone derivatives selectively act as bactericidal agents on Helicobacter pylori, a pathogen responsible for gastric cancer in human, but have no influence on the survival of other representative bacteria such as enterobacteria. These results indicate that progesterone could be a convenient structure for development of steroidal antibacterial medicines in the eradication of H. pylori in human stomach.

Free Research Field

細菌学

URL: 

Published: 2017-05-10  

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