2015 Fiscal Year Annual Research Report
| Project/Area Number |
25460545
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| Research Institution | Kitasato University |
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Principal Investigator |
松井 英則 北里大学, 感染制御科学府, 講師 (30219373)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 細菌 / 感染症 / CD46 / マウス感染モデル / レンサ球菌 / レンサ球菌毒素生ショック症候群 / 骨破壊 / RANKL |
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| Outline of Annual Research Achievements |
当初の目標は、平成26年度に得た以下の内容を論文にまとめることであった。(1) MTB313とMTB314の全ゲノム解析。(2) MTB313の強毒化機構の解析。(3) GAS472感染による骨壊死の誘導機構の解析。
結果
(1)について、Comparative genomics of mucoid and nonmucoid strains of Streptococcus pyogenes isolated from the same patient with streptococcal meningitis. Haruno Yoshida, Yasuhito Ishigaki, Asako Takizawa, Kunihiko Moro, Yuki Kishi, Takashi Takahashi, and Hidenori Matsui (corresponding author). Genome Announcements 2015, 3 (2), e00221-15.
(2)については、論文投稿準備中.
(3)については、Fresh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-kappaB ligand. Hidenori Matsui (corresponding author),Yuriko Nakatani,Haruno Yoshida, Asako Takizawa, Osamu Takeuchi, Anders Overby, Takashi Takahashi, Somay Y. Murayama, and Koichi Matsuo. Cellular Microbiology, 22 Mar., 2016. doi: 10.1111/cmi.12581.
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[Journal Article] Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-kappaB ligand2016
Author(s)
Matsui, H., Nakatani, Y., Yoshida, H., Takizawa, A., Takeuchi, O., Overby, A., Takahashi, T., Murayama, S. Y., Matsuo, K.
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Journal Title
Cellular Microbiology
Volume: 18
Pages: 1-15
DOI
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A highly susceptible CD46 transgenic mouse model of subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis2016
Author(s)
Yoshida, H., Takahashi, T., Nakamura, M., Overby, A., Takahashi, T., Ubukata, K., Matsui, H.
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Journal Title
Journal of Infection and Chemotherapy
Volume: 22
Pages: 229-234
DOI
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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