Protective immunity against Bordetella holmesii

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: Kitasato University
• Principal Investigator: Watanabe Mineo 北里大学, 大学院感染制御科学府, 准教授 (40279245)
• Co-Investigator(Kenkyū-buntansha): KAMACHI Kazunari 国立感染症研究所, 細菌第二部, 室長 (10260275)
• Research Collaborator: SUZUKI Eri ; SAITO Momoko ; YAMAGUCHI Tetsuya
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ワクチン / 百日咳 / 病原性 / Bordetella / 再興感染症 / 新興感染症 / 小児 / 呼吸器

Outline of Final Research Achievements

Pertussis (whooping cough) is a highly contagious respiratory disease caused by Bordetella pertussis and Bordetella parapertussis. Recently, Bordetella holmesii has being mentioned as the third causative agent of pertussis. Epidemiological studies clearly suggested importance of control of B. holmesii infection in humans.
In this study, we developed effective vaccines against B. holmesii infection in a mouse model. Also, we determined a protective antigen of B. holmesii. Our results will help development of modified pertussis vaccines that are effective to all causative agents of pertussis.

Free Research Field

病原細菌学、ワクチン学