2015 Fiscal Year Final Research Report
Establishment of the molecular bases for development of the next-generation Streptococcus pneumoniae vaccine
| Project/Area Number |
25460555
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
OGAWA Michinaga 国立感染症研究所, その他部局等, 室長 (80361624)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 肺炎球菌 / 病原性 / 次世代ワクチン |
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| Outline of Final Research Achievements |
In this study, I aimed at revealing the function of the pneumococcal virulence factor and the interaction of intracellular pneumococci and host cells.
As a result of intracellular survivability test using 40 kinds of gene-targeted deletion mutants, it was revealed that 14 pneumococcal virulence factors play pivotal role in the survivability of pneumococci in host cells.
Next, I examined 58 kinds of Rab proteins in their co-localization with intracellular pneumococci, and 10 Rab protein were revealed to be targeted to the endosomes engulfing pneumococci.
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| Free Research Field |
細菌学
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