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2015 Fiscal Year Final Research Report

Establishment of the molecular bases for development of the next-generation Streptococcus pneumoniae vaccine

Research Project

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Project/Area Number 25460555
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

OGAWA Michinaga  国立感染症研究所, その他部局等, 室長 (80361624)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords肺炎球菌 / 病原性 / 次世代ワクチン
Outline of Final Research Achievements

In this study, I aimed at revealing the function of the pneumococcal virulence factor and the interaction of intracellular pneumococci and host cells.
As a result of intracellular survivability test using 40 kinds of gene-targeted deletion mutants, it was revealed that 14 pneumococcal virulence factors play pivotal role in the survivability of pneumococci in host cells.
Next, I examined 58 kinds of Rab proteins in their co-localization with intracellular pneumococci, and 10 Rab protein were revealed to be targeted to the endosomes engulfing pneumococci.

Free Research Field

細菌学

URL: 

Published: 2017-05-10  

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