2015 Fiscal Year Final Research Report
Establishment of novel anti-virus strategy targeting HIV-1 RNA psi pseudoknot.
| Project/Area Number |
25460567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | HIV-1 / RNA / ウイルスゲノム / パッケージング / 二量体化 |
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| Outline of Final Research Achievements |
The genome of HIV-1 always forms dimer in virion. The genome dimerization is believed to have important roles on viral infectivity and/or pathogenicity. Previously I suggested the dimerization signal region RNA (DLS) of HIV-1 forms pseudoknot-like structure. In this project, I explored a precise functional structures around the pseudoknot, such as SL1 and primer binding site applying virological/molecular biological approach. In addition, I focused on the p1 region, which is important for viral maturation process and examined its roles on viral infectivity and genome packaging.
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| Free Research Field |
ウイルス学
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